Table 2.
Sensitivities, specificities, and accuracy values for the differentiation between different clinical entities by %normal myocardium, LGE data and by combining both
| Clinical entities | Parameters | Sensitivity | Specificity | AUC | p-values |
|---|---|---|---|---|---|
| A. All patients | |||||
| Athletes vs. HCM | %normal myocardium | 98% | 100% | 0.99 | 0.08§ |
| Athletes vs. HCM | Atypical LGE | 98% | 83% | 0.90 | |
| Athletes vs. HHD | %normal myocardium | 67% | 91% | 0.84 | 0.001§ |
| Athletes vs. HHD | Atypical LGE | 42% | 83% | 0.61 | |
| HHD vs. HCM | %normal myocardium | 47% | 98% | 0.78 | 0.03§ |
| Atypical LGE | 74% | 91% | 0.88 | ||
| %normal myocardium and LGE* | 82% | 98% | 0.92 | ||
| HCM vs. amyloidosis | %normal myocardium | 56% | 91% | 0.82 | 0.7§ |
| Atypical LGE | 70% | 96% | 0.81 | ||
| %normal myocardium and LGE** | 80% | 100% | 0.94 | ||
| B. Patients with mild to moderate hypertrophy (IVS 11–15 mm) | |||||
| Athletes vs. HCM | %normal myocardium | 100% | 100% | 1.0 | 0.16§ |
| Athletes vs. HCM | Atypical LGE | 100% | 75% | 0.84 | |
| Athletes vs. HHD | %normal myocardium | 83% | 75% | 0.86 | 0.003§ |
| Athletes vs. HHD | Atypical LGE | 41% | 75% | 0.56 | |
| HHD vs. HCM | %normal myocardium | 45% | 100% | 0.78 | 0.04§ |
| Atypical LGE | 86% | 85% | 0.90 | ||
| %normal myocardium and LGE* | 82% | 100% | 0.92 | ||
| HCM vs. amyloidosis | %normal myocardium | 85% | 50% | 0.73 | 0.11§ |
| Atypical LGE | 83% | 100% | 0.83 | ||
| %normal myocardium and LGE** | 83% | 100% | 0.83 | ||
| C. All patients (Cut-off values derived from cohort A and applied to cohort B; mean AUC values of cohorts A&B are provided) | |||||
| Athletes vs. HCM | %normal myocardium | 100% | 100% | 0.99 | 0.10§ |
| Athletes vs. HCM | Atypical LGE | 100% | 67% | 0.81 | |
| Athletes vs. HHD | %normal myocardium | 73% | 91% | 0.84 | 0.008§ |
| Athletes vs. HHD | Atypical LGE | 48% | 67% | 0.55 | |
| HHD vs. HCM | %normal myocardium | 39% | 100% | 0.78 | 0.42§ |
| Atypical LGE | 64% | 91% | 0.87 | ||
| HCM vs. amyloidosis | %normal myocardium | 56% | 91% | 0.83 | 0.38§ |
| Atypical LGE | 77% | 68% | 0.82 | ||
AUC area under the curve, HCM hypertrophic cardiomyopathy, HHD hypertensive heart disease, LGE late gadolinium enhancement, IVS intraventricular septum
*For the combined approach, patients with no atypical LGE were classified as HHD, whereas in patients with one or more segments with atypical LGE classification was performed by %normal myocardium
**For the combined approach, patients with ≥ 10 segments atypical LGE were classified as cardiac amyloidosis, whereas in patients with < 10 segments atypical LGE, classification was performed by %normal myocardium
§For comparison of atypical LGE vs. %normal myocardium