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. 2021 Jul 12;21:284. doi: 10.1186/s12876-021-01869-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Comparison of miRNA, and protein expression in different TGF-β status. a Correlation between the first principal component (PC1) of the expression of TGF-β^low-specific miRNAs and their predicted targeted TGF-β^high-specific mRNAs. b The heatmap shows the most significantly down-regulated 20 miRNAs in the TGF-β^high group across each GIAD. c A network Schematic diagram of miR-215-3p, miR-378a-5p, and miR-194-3p and their predicted targeting TGF-β^high-specific mRNA in stomach adenocarcinoma. d Negative correlation between miR-194-3p expression and TGF-β score in 4 types of GIAD (Pearson correlation). e The significantly differential proteins in TGF-β^high and TGF-β^low groups; Red indicates high protein expression in the TGF-β^high group, and blue indicates high protein expression in the TGF-β^low group