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| compd | mGO IC50 (nM) | mLDHA IC50 (nM) | mouse primary hepatocyte (pyruvate to lactate) IC50 (nM) | AgxtKD mouse primary hepatocyte (glycolate to oxalate) IC50 (nM) |
|---|---|---|---|---|
| 7 | 7.7 | 0.8 | 136 | 88 |
| A | 14.6 | 149 | ||
| 63 | 0.1 | 181b |
See Supporting Information for assay conditions. All IC50 values are mean values determined from more than two replicates unless otherwise specified.
IC50 value from n = 1 experiment.
