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| route | dose (mg/kg) | tissue | Cl (mL/min/kg) | Vss (L/kg) | t1/2 (hr) | AUC0–24 h (ng/mL*hr) | Cmax (ng/mL) | Tmax (hr) | F (%) |
|---|---|---|---|---|---|---|---|---|---|
| IVb | 2.32 | plasma | 6.09 | 2.36 | 4.72 | 6170 | 1270 | ||
| brain | 3020 | 274 | 3.00 | ||||||
| POb,c | 10 | plasma | 12200 | 1070 | 3.00 | 51 | |||
| brain | 8840 | 823 | 7.00 |
In male C57BL/6 mice (n = 3).
Formulation IV, and PO, solution in 15%HPCD.
Kp,uu = 0.11.
