Table 6. HBD-Reduced Lipophilic Peptides.
| peptide | IC50 (h/m), nMa | cell-based IC50, μMb | CC20, μMc | No. HBD | AlogP |
|---|---|---|---|---|---|
| 1 | 28/25 | >100 | >100 | 14 | 0.38 |
| 23 | 0.15/0.15 | >100 | >100 | 11 | 2.41 |
| 25 | 0.40/0.62 | 3.7 | >100 | 6 | 6.25 |
| 26 | 1.9/2.0 | 0.77 | >100 | 5 | 6.14 |
a
Values represent an average of at least two experiments.
b
Values were determined using NNMT-overexpressed HEK293 cells and represent an average of at least two experiments.
c
Values represent the concentration of peptides to indicate 20% ATP decline in the cells.