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. 2021 Jun 25;12(7):1159–1165. doi: 10.1021/acsmedchemlett.1c00277

Figure 2.

Figure 2

Effects of 8, 26, and 30 on human PXR activation. (A) Dual-luciferase reporter gene assay was performed in HEK293T cells transiently transfected with expression vectors encoding human PXR (pSG5-hPXR), reporter plasmid (pGL3-CYP3A4-XREM-Luc), and the control plasmid (pRL-TK). Cells were treated with the positive agonist RIF (10 μM) or compounds 1–34 (10 μM) for 24 h. (B) Dose–response assay for 8, 26, 30, and RIF (0.1, 0.5, 1, 5, 10, and 50 μM). Data are presented as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, versus the vehicle.