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RT-qPCR analysis was used to detect the expressions of the PXR downstream genes (A) CYP3A4, (B) CYP2B6, and (C) MDR1 in HepaRG cells after treatment of RIF (10 μM) and compounds 8, 26, and 30 (10 μM). Values were relative to house-keeping gene β-ACTIN. Data were presented as mean ± SD (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, versus the vehicle.
