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. 2021 May 3;13(4):1398–1407. doi: 10.1111/os.13000

Fig. 3.

Fig. 3

PSTPIP2 overexpression attenuates cartilage injury and inhibits ERK phosphorylation in DM‐OA rats. (A) Representative safranin O/fast green‐stained cartilage histological images and OARSI scores for all groups. (B) Western blotting analysis of MMP‐3, MMP‐13, ADAMTS‐5, ICAM‐1 and β‐actin proteins in synovial tissues for all groups. (C) Western blotting analysis of p‐ERK, ERK and β‐actin proteins in synovial tissues for all groups. *P < 0.05, ****P < 0.0001. n = 6. Ctrl, control; DM‐OA, diabetes mellitus‐osteoarthritis; LV‐NC, negative control lentivirus transfected; LV‐PSTPIP2, PSTPIP2 overexpression lentivirus transfected.