FIGURE 3.

Assessment of autoimmunity in the tumor necrosis factor (TNF) family‐transgenic (BAFF‐Tg) mice treated with TNF inhibitor (TNFi). Assessment of the cellular composition of the spleen by flow cytometry performed at euthanasia in 10 mice treated with control, 14 treated with eternacept (ETA) and 11 mice treated with adalimumab (ADA) and focused on (a) marginal zone (MZ) B cells, (b) follicular (Fo) B cells, (c) T1 B cells and (d) T2 B cells. (e) Anti‐dsDNA antibodies, (f) rheumatoid factor (RF) titers and immunoglobulin (Ig)M (g) and IgG (h) concentrations measured in the sera of the mice at euthanasia (18 in the control group, 12 in the group treated with eternacept (ETA), six in the group treated with ADA and 12 in the group treated with TN3). Results are shown as mean and standard deviation (s.d.). Kruskal–Wallis test followed by Dunn’s multiple comparison test. *p < 0.05, **p < 0.01