FIGURE 3.

Stimulation‐induced RA peripheral blood mononuclear cell (PBMC) cytokines. (a) CD40L/phorbol myristate acetate (PMA)/ionomycin stimulation significantly increased interferon (IFN)‐γ (P = 0.003), tumor necrosis factor (TNF)‐α (P = 0.001), interleukin (IL)‐6 (P = 0.0002), IL‐17 (P = 0.007) and IL‐10 (P = 0.002) in rheumatoid arthritis (RA) peripheral blood mononuclear cell (PBMC) cultures. Tofacitinib treatment significantly reduced IL‐6 (P = 0.002), IL‐17 (P = 0.03) and IL‐10 (P = 0.0007) levels. (b) Collagen stimulation reduced IL‐10 levels, while tofacitinib treatment increased IL‐10 and IL‐6 levels. Results are presented as median and interquartile range