FIGURE 6.

Effect of 16α‐bromoepiandrosterone (BEA) in the liver of tuberculosis (TB) and type 2 diabetes mellitus (T2D)/TB mice. Liver samples from groups of five T2D and T2D/TB mice treated with BEA for 1 month and their respective control mice that received only the vehicle were used to isolate total RNA and 11‐β‐hydroxysteroid dehydrogenase type 1 (1‐βHSD1) (a) and 11‐βHSD2) (b) mRNA determination by reverse transcription–polymerase chain reaction (RT–PCR). (c) Treatment with BEA corrected hyperglycemia in T2D and T2D/TB mice. Asterisks represent statistical significance [***p < 0.0001, ****p < 0.0001, two‐way analysis of variance (anova), n.s. = without significance]. D) Liver tissue sections stained with hematoxylin and eosin (H&E) revealed steatosis in T2D and T2D/TB mice, which was reverted by treatment with BEA