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. 2021 Jul;100(1):73–82. doi: 10.1124/molpharm.120.000195

TABLE 2.

Census of robotic operation and operator interaction time for the propofol case study

Total Operation Electrode Cleaning
(Robotic Control)
Data Collection
(Robotic Control)
Patch Establishment
(Operator Control)
Nonrecording Timea
Total time
(percent)
12.95 h 1.39 h
(10.7%)
9.07 h
(70.0%)
2.49 h
(19.3%)
3.88 h
(30%)
Time per cycle
(successful cycle)
1.99 min 24.6 min 3.55 min 5.54 min
Time per data point
(successful cycle)
4.1 minb



2.1 minc

aThe nonrecording time is the time the robot is not performing the data collection protocol.

bEach data collection phase equals the solution change time (∼1 min solution change time) plus the data collection time (1.67 min data collection); however, the mean time per data point reflects the additional time needed to pull the patch and validate the jump at the end of the experiment averaged into the timing for each phase.

cThis rate represents the total time the operator spent interacting with the patcherBotPharma during the entire experiment performance (cell selection, solution maintenance, electrode placement on the cell, and gigaseal formation). The theoretical maximal efficiency of data collection per the operator’s effort would be 0.97 min of the operator’s time per data point.