Table 2a.
Clinical Cohort Characteristics – patients were balanced with regards to age and clinical tumor stage. Highly radioresistant sarcomas had a large proportion of low grade disease, retroperitoneal primary site, and higher positive margin rate. Institutional practice considers a positive margin to include disease suspicious for well-differentiated liposarcoma at ink. Of the HRR patients with positive margins, only 7 had high-grade/dedifferentiated liposarcoma at the surgical margin.
| Characteristic |
Overall |
Highly Radioresistant (HRR) |
Conventionally Radioresistant (CRR) |
Chi Square | ||||
|---|---|---|---|---|---|---|---|---|
| (p value) | ||||||||
| N | % | N | % | N | % | |||
| Age | Age <50 years | 86 | 21.6% | 15 | 22.4% | 71 | 21.4% | 0.86 |
| Age ≥50 years | 313 | 78.4% | 52 | 77.6% | 261 | 78.6% | ||
| Tumor Stage | cT1a | 7 | 1.8% | 1 | 1.5% | 6 | 1.5% | 0.61 |
| cT1b | 39 | 9.8% | 5 | 7.5% | 34 | 8.5% | ||
| cT2a | 30 | 7.5% | 3 | 4.5% | 27 | 6.8% | ||
| cT2b | 280 | 70.2% | 51 | 76.1% | 229 | 57.4% | ||
| Unknown stage | 43 | 10.8% | 7 | 10.4% | 36 | 9.0% | ||
| Grade | Low grade | 16 | 4.0% | 10 | 14.9% | 6 | 1.8% | <0.01 |
| High grade | 223 | 55.9% | 36 | 53.7% | 187 | 56.3% | ||
| Unknown | 160 | 40.3% | 21 | 31.3% | 139 | 41.9% | ||
| Primary Site | Extremity | 241 | 60.4% | 23 | 34.3% | 218 | 65.7% | <0.01 |
| Retroperitoneal | 88 | 22.1% | 32 | 47.8% | 56 | 16.9% | ||
| Other | 70 | 17.5% | 12 | 17.9% | 58 | 17.5% | ||
| Surgical Margins | Negative | 274 | 68.7% | 31 | 46.3% | 243 | 73.2% | <0.01 |
| Positive | 115 | 28.8% | 36 | 53.7% | 79 | 23.8% | ||
| Unknown | 10 | 2.5% | 0 | 0.0% | 10 | 3.0% | ||