Table 3.
Multivariate Analysis for locoregional control demonstrated HRR histology as an independent predictor of worse locoregional control, even when evaluating for other features that are traditionally considered as risk factors for recurrence such as age, margin status, clinical T-stage, and primary site.
| Characteristic | Hazard ratio | 95% Confidence Interval | P-value |
|---|---|---|---|
| Age <50 years | 1.00 | Ref | - |
| Age ≥50 years | 1.35 | 0.59–3.10 | 0.48 |
| Margin status | |||
| Negative surgical margins | 1.00 | Ref | - |
| Positive surgical margins | 1.87 | 0.93–3.80 | 0.08 |
| Clinical T-stage | |||
| T1 | 1.00 | Ref | - |
| T2 | 0.70 | 0.33–2.10 | 0.84 |
| Histology | |||
| Highly Radioresistant | 2.54 | 1.23–5.22 | 0.01 |
| Conventionally Radioresistant | 1.00 | Ref | - |
| Primary site | |||
| Extremity | 1.00 | Ref | - |
| Retroperitoneum/Pelvis | 0.64 | 0.27–1.53 | 0.32 |
| Other | 1.09 | 0.46–2.53 | 0.85 |