Figure 3.

A2 cell-specific deletion in endothelial cells reduced I/R-induced neurodegeneration. A) Confocal imaging of retinal flatmounts labeled with the neuronal marker (NeuN) and quantification (B) showing a significant increase in NeunN positive cells (arrows) in endothelial specific A2 Knockout (E-A2 KO) retinas subjected to I/R. LoxP mice were used as controls. Data are presented as percent of LoxP sham. Myeloid specific A2 knockout (M-A2 KO) did not show protection against I/R-induced neuronal loss. Data are presented as mean ± SD.