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. 2021 Jun 15;53:101273. doi: 10.1016/j.molmet.2021.101273

Figure 4.

Figure 4

OGD/R induces an increase in A2 expression along with increases in cell stress in BREC, and arginase inhibition prevented this effect. A) and C) Western blot analysis with quantification (B and D) showing increased expression of A2 after OGD/R in BRECs compared to normoxia. There was no change in A1 protein levels. ∗P < 0.05 vs. normoxia. n = 3. E) Western blot analysis with quantification (F and G) showing increased protein levels of phospho p38MAPK and cleaved PARP after OGD/R in BRECs compared to normoxia. ABH treatment significantly protected against OGD/R-induced phosphorylation of p38. ∗∗P < 0.01 vs. Normoxia, #P < 0.01 vs. OGD/R, $p < 0.001 vs. Normoxia. n = 3. Data are presented as mean ± SD.