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. Author manuscript; available in PMC: 2021 Jul 12.
Published in final edited form as: Science. 2020 Oct 30;370(6516):eaaz0868. doi: 10.1126/science.aaz0868

Fig. 3. Pathways associated with the physical traits of cancer.

Fig. 3.

Physical traits of cancer activate a large cascade of mechanoresponsive pathways in cancer cells and stromal cells, including endothelial, epithelial, mesenchymal, and immune cells. Pathways such as integrin and YAP/TAZ are responsive to all four physical traits, whereas many other pathways appear to be more specific.