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. Author manuscript; available in PMC: 2021 Jul 12.
Published in final edited form as: J Am Chem Soc. 2021 Apr 27;143(18):7196–7202. doi: 10.1021/jacs.1c03004

Figure 2.

Figure 2.

(a) Normalized absorbance spectra of APNO-1080 with (red) and without (blue) NO treatment. (b) Photostability assay in which APNO-1080 or the N-nitrosated product (50 μM) is continuously irradiated with a pulsed laser at their respective λabs for 300 s. (c) Reaction of APNO-1080 (5 μM) with biologically relevant metal ions (1 mM), GSH (1 mM), Cys (500 μM), H2S (100 μM), reactive oxygen species (1 mM), reactive carbonyl species (1 mM), reactive nitrogen species (1 mM), ONOO− (50 μM), and NO (100 μM) after 1 h incubation. (d) MTT viability assay in A549 cells after 24 h incubation at 37 °C.