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. 2021 Jun 25;8:644508. doi: 10.3389/fcvm.2021.644508

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Copyright © 2021 Sabbour, Hasan, Al Badarin, Alibazoglu, Rivard, Romany and Perlini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cardiac MRI (A,B) showing biatrial enlargement without evidence of infiltrative disease. Planar bone scintigraphy (^99mTc-PYP) at 1 h (C) and 3 h (D) showing myocardial PYP uptake greater than rib uptake (grade 3) via semi-quantitative assessment—strongly suggestive of ATTR-CM. SPECT scan (E) at 1 h showing no blood pool. ^99mTc-PYP, ^99mtechnetium-labeled pyrophosphate; ATTR-CM, transthyretin amyloid cardiomyopathy; MRI, magnetic resonance imaging; PYP, pyrophosphate; SPECT, single-photon emission computed tomography.