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. Author manuscript; available in PMC: 2022 Apr 7.
Published in final edited form as: Biomater Sci. 2021 Jan 13;9(7):2494–2507. doi: 10.1039/d0bm01372b

Figure 7. Analysis of inflammation induced following subcutaneous injection of CATCH(+/−) hydrogels into C57BL/6J mice.

Figure 7.

(a) Fold change in paw thickness after injection of 12 mM CATCH(4+/6−) hydrogel (red square), 12 mM CATCH(6+/4−) hydrogel (blue triangle), λ-carrageenan (green circle, positive control), relative to PBS vehicle injected into contralateral paw (vehicle control). (b-c) Representative digital photographs of mouse paws at t = 24 or 144 h after injection of 12 mM CATCH(4+/6−) or λ-carrageenan. (d-f) Representative histology sections taken from tissues at t = 144 h after injection of PBS vehicle, 12 mM CATCH(4+/6−) hydrogel, or λ-carrageenan. (g) Infiltrate thickness score at t = 24 and 144 h after injection of PBS vehicle, 12 mM CATCH(4+/6−) hydrogel, or λ-carrageenan determined from histology sections. Data presented as mean ± standard deviation (n = 5) in (a). *** represents p < 0.001, repeated measures ANOVA with Dunnett’s multiple comparison. Data presented as mean ± standard deviation (n = 3) ANOVA with Tukey’s post-hoc in (g).