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(A) Structure of Lck kinase domains; (B) Schematic structure of Lck: SH4, unique region (UR), SH3, SH2, SH2-kinase domain linker region (LR), kinase domain, and the C-terminal negative regulatory tail (NR), Reprinted from Ref.4; (C) Lck conformations and regulation of Lck activation, Reprinted from Ref.4.
