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. 2021 Jul 8;59(1):910–919. doi: 10.1080/13880209.2021.1944222

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Comparison of BBB permeability and protein expression in TIV-treated CUMS mice and controls. (A) ZO-1 expression in TIV-treated CUMS mice. (B) Occludin expression in TIV-treated CUMS mice. (C) Changes in BBB permeability. (D) Observation of TJ ultrastructure changes in the BBB by transmission electron microscopy. The red arrow indicates a break or discontinuity in the basement membrane. Data are reported as mean ± SD. # p < 0.05 and ## p < 0.01 vs. the normal group. *p < 0.05 and **p < 0.01 vs. the model group. N: normal; M: model; S: fluoxetine; L: TIV-L; Me: TIV-M; H: TIV-H (n = 3 per group).