Table 1:

Characteristics of rs2642438 homozygous or heterozygous Carriers compared with non-carriers in UKB.

	Non carriers (G/G) n=227 685	Heterozygotes (G/A) n=191 936	Homozygotes (A/A) n=40 591	p-Value G/G vs G/A	p-Value G/G vs A/A
Characteristics				Univ.	Univ.
Age (years)	56.6±8.1	56.8±8.0	56.8±8.0	.11	.089
Women (%)	55	54	54	.18	.11
BMI (kg/m2)	27.4±4.8	27.4±4.8	27.4±4.8	.24	.55
Alcohol (g/d)	8.9±10.1	9.0±10.2	9.2±10.1	.038	.00002
Diabetes mellitus (%)	5	5	5	.59	.085
Ethnicity (% white)	100	100	100
Frequency of well-known NAFLD influencing genes*
HSD17B13 rs72621367:TA	0.55±0.63	0.55±0.63	0.55±0.63	.10	.18
PNPLA3 rs738409:G	0.43±0.58	0.43±0.58	0.43±0.58	.34	.26
Liver status				Multiv,	Multiv.
ALT (U/l)	23.7±14.5	23.3±13.9	22.8±13.4	1.8*10-25	7.2*10-38
AST (U/l)	26.2±10.8	26.0±10.2	25.9±9.9	.0001	3.3*10-9
GGT (U/l)	37.1±41.9	36.8±41.0	36.8±37.5	.009	.11
Bilirubin (mg/dl)	0.54±0.26	0.53±0.26	0.53±0.26	.000009	.000009
AP (U/l)	83.9±26.3	83.3±26.0	82.6±26.8	2.8*10-16	3.7*10-22
Lipid metabolism
Triglycerides (mg/dl)	154±89	156±91	157±91	.000008	1.1*10-9
HDL cholesterol (mg/dl)	57±15	56±15	55±15	9.2*10-18	1.6*10-26
LDL cholesterol (mg/dl)	138±34	137±34	136±34	9.8*10-15	5.3*10-20
Cholesterol (mg/dl)	221±44	219±44	220±44	3.7*10-19	2.4*10-25
Apolipoprotein A1 (g/l)	1.54±0.27	1.54±0.27	1.53±0.27	2.5*10-19	1.1*10-29
Apolipoprotein B (g/l)	1.04±0.24	1.03±0.24	1.03±0.24	5.9*10-7	1.7*10-8
Lipoprotein A (nmol/l)	44.05±48.9	44.04±49.4	44.08±49.4	.99	.90
Additional serum parameters
Urate (umol/L)	308.2±80.0	309.0±80.4	310.2±80.4	.011	.00001
Vitamin D (nmol/L)	49.2±20.9	49.5±21.0	49.8±21.2	.000005	4.7*10-8
IGF-1 (nmol/l)	21.3±5.8	21.5±5.6	21.6±5.6	3.2*10-14	2.2*10-16

Quantitative measures are expressed as means and standard deviations or as relative frequencies (%). All multivariable analyses were adjusted for age, sex, BMI, and PC1-4.

^*(0=non carrier, 1=heterozygous, 2=homozygous). A FDR adjusted significance level of p <= 0.03 was used.