Table 2:
Characteristics of rs2642438 homozygous or heterozygous carriers compared with non-carriers in UKB.
| Non carriers (G/G) n=227 685 |
Heterozygotes (G/A) n = 191 936 |
Homozygotes (A/A) n=40 591 |
p-Value G/G vs G/A |
p-Value G/G vs A/A |
aOR G/G vs G/A |
aOR G/G vs A/A |
|
|---|---|---|---|---|---|---|---|
| Liver status | |||||||
| ALT ≥ULN, N(%) | 15 531 (6.8) | 11 999 (6.3) | 2 211 (5.4) | 1.3*10-13 | 2.7*10-25 | 0.91 [0.89-0.93] | 0.78[0.74-0.82] |
| AST ≥ULN, N(%) | 10 317 (4.5) | 8 357 (4.4) | 1 664 (4.1) | .008 | .00001 | 0.96[0.93-0.99] | 0.90[0.85-0.95] |
| ICD10 coded diagnoses | |||||||
| Overall liver disease (K70-K76), N(%) | 3 609 (1.59) | 2 874 (1.50) | 580 (1.43) | .015 | .010 | 0.94[0.89-0.99] | 0.89[0.81-0.97] |
| Alcoholic liver disease (K70), N(%) | 516 (0.23) | 397 (0.21) | 78 (0.19) | .17 | .16 | ||
| Toxic liver disease (K71), N(%) | 40 (0.02) | 39 (0.02) | 6 (0.01) | .45 | .48 | ||
| Hepatic failure (K72), N(%) | 258 (0.11) | 177 (0.09) | 41 (0.10) | .050 | .90 | ||
| Chronic Hepatitis (K73), N(%) | 78 (0.03) | 68 (0.04) | 14 (0.03) | .80 | .99 | ||
| Fibrosis and cirrhosis (K74), N(%) | 575 (0.25) | 467 (0.24) | 73 (0.18) | .59 | .007 | ||
| Inflammatory liver diseases (K75), N(%) | 481 (0.25) | 404 (0.24) | 80 (0.24) | .85 | .52 | ||
| NASH (K75.8), N(%) | 170 (0.07) | 129 (0.07) | 19 (0.05) | .32 | .044 | ||
| Other liver diseases (K76), N(%) | 2 650 (1.16) | 2 071 (1.08) | 403 (0.99) | .006 | .001 | 0.92[0.87-0.98] | 0.84[0.75-0.93] |
| NAFLD (K76.0), N(%) | 1 347 (0.59) | 991 (0.52) | 191 (0.47) | .0004 | .002 | 0.86[0.79-0.94] | 0.78[0.67-0.91] |
| Malignant neoplasm of the liver and/or bile duct (C22), N(%) | 268 (0.12) | 200 (0.10) | 35 (0.09) | .17 | .072 | ||
| Survival | |||||||
| All-cause mortality, N(%) | 14 045 (6) | 12 061 (6) | 2501 (6) | .71 | .35 | ||
| Liver related death, N(%) | 474 (0.21) | 345 (0.18) | 52 (0.13) | .030 | .001 | 0.86[0.74-0.99] | 0.61[0.46-0.81] |
| Cardiovascular death, N(%) | 2 734 (1.2) | 2 338 (1.2) | 544 (1.3) | .63 | .35 |
Quantitative measures are expressed as number of participants (N) and as relative frequencies (%). All multivariable analyses were adjusted for age, sex, BMI, and PC1-4). A FDR adjusted significance level of p <= 0.03 was used.