Table 3:

Baseline characteristics of homozygous (G/G) or heterozygous rs2642438 carriers (G/A) compared with non-carriers (A/A) in PMBB.

	Non carriers (G/G) n=9 581	Heterozygotes (G/A) n=3 889	Homozygotes (A/A) n=594	p-Value G/G vs G/A	p-Value G/G vs A/A
Characteristics				Univ.	Univ.
Age (years)	60.6±17.3	65.9±13.9	69.5±15.4	1.7*10-64	4.1*10-13
Women (%)	57	48	41	2.0*10-18	1.9*10-37
BMI (kg/m2)	29.0±5.9	30.0±6.1	28.4±5.3	3.5*10-21	6.8*10-21
Diabetes mellitus (%)	26	24	22	.048	.040
Ethnicity (% Whites)	33	68	88	4.6*10-306	5.0*10-185
Frequency of well-known NAFLD influencing genes*
HSD17B13 rs72621367:TA	0.55±0.63	0.56±0.63	0.57±0.63	.51	.95
PNPLA3 rs738409:G	0.35±0.58	0.41±0.58	0.46±0.58	.47	.67
Liver status				Multiv.	Multiv.
ALT (U/l)	24.4±36.1	23.6±17.8	23.9±17.0	.001	.034
ALT ≥ULN (%)	7	7	6	.22	.064
AST (U/l)	25.3±44.8	24.0±15.7	24.0±17.9	.006	.12
AST ≥ULN (%)	6	6	6	.021a	.86
Lipid metabolism
Triglycerides (mg/dl)	112±78	119±69	128±69	.041	.029
HDL cholesterol (mg/dl)	50±15	50±17	48±16	.37	.062
LDL cholesterol (mg/dl)	100±33	95±32	90±34	.057	.052
Cholesterol (mg/dl)	174±39	169±39	163±38	.035	.011
ICD10 coded diagnoses
Toxic liver disease (K71)	0.7	0.6	0.5	.20	.22
Hepatic failure (K72)	1.0	0.9	1.0	.99	.77
Chronic Hepatitis (K73)	0.7	0.05	0.0	.59	.99
Fibrosis and cirrhosis (K74)	0.4	0.4	0.2	.90	.23
Inflammatory liver diseases (K75)	2.2	1.8	1.3	.019b	.10
NASH (K75.8)	2.2	2.0	1.9	.065	.28
Other liver diseases (K76)	4.0	3.5	2.2	.14	.052
NAFLD (K76.0)	3.0	2.5	1.5	.021c	.030d

Quantitative measures are expressed as means and standard deviations or as relative frequencies (%). All multivariable analyses were adjusted for age, sex, BMI, and PC1-4.

^*(0=non carrier, 1=heterozygous, 2=homozygous);

^aaOR=0.81[0.67-0.97]

^baOR=0.71 [0.54-0.94]

^caOR=0.85[0.69-0.96]

^daOR=0.70[0.50-0.98]. A FDR adjusted significance level of p <= 0.03 was used.