Table 3. . Area under the receiver operating characteristics curve to predict acute kidney injury, relative to aminoglycoside treatment day.
| Treatment day | AUC (95% CI) to predict any stage AKI | AUC (95% CI) to predict severe AKI |
|---|---|---|
| NGAL (ng/ml) | ||
| 2 | 0.43 (0.25–0.61) | 0.40 (0.19–0.62) |
| 3 | 0.39 (0.18–0.61) | 0.47 (0.03–0.91) |
| 4 | 0.69 (0.40–0.98) | 0.87 (0.76–0.98) |
| IL18 (pg/ml) | ||
| 2 | 0.63 (0.39–0.86) | 0.59 (0.19–0.99) |
| 3 | 0.33 (0.17–0.49) | 0.81 (0.70–0.91) |
| 4 | 0.52 (0.28–0.76) | 0.52 (0.00–1.00) |
| KIM1 (pg/ml) | ||
| 2 | 0.66 (0.45–0.86) | 0.59 (0.23–0.94) |
| 3 | 0.49 (0.23–0.76) | 0.42 (0.00–0.92) |
| 4 | 0.53 (0.34–0.70) | 0.46 (0.21–0.71) |
| TIMP2 (ng/ml) | ||
| 2 | 0.64 (0.48–0.80) | 0.66 (0.45–0.87) |
| 3 | 0.69 (0.49–0.88) | 0.70 (0.19–1.00) |
| 4 | 0.64 (0.44–0.83) | 0.72 (0.40–1.00) |
| IGFBP7 (ng/ml) | ||
| 2 | 0.69 (0.53–0.85) | 0.71 (0.47–0.94) |
| 3 | 0.46 (0.25–0.67) | 0.48 (0.07–0.89) |
| 4 | 0.60 (0.33–0.87) | 0.71 (0.25–1.00) |
| TIMP2*IGFBP7 (ng/ml)2/1000 | ||
| 2 | 0.72 (0.57–0.87) | 0.76 (0.55–0.96) |
| 3 | 0.39 (0.17–0.62) | 0.40 (0.00–0.90) |
| 4 | 0.49 (0.27–0.72) | 0.54 (0.18–0.90) |
Bolded AUCs: 95% CI did not cross 0.5.
AKI: Acute kidney injury; AUC: Area under the curve.