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. 2021 Jul 12;95(15):e02350-20. doi: 10.1128/JVI.02350-20

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Copyright © 2021 Rubio et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 8 — D5_AR is not potentiated as a Fab and shows minimal or no potentiation in the presence of other Fc receptors. (A) Neutralization curves for D5_AR Fab against lentivirus pseudotyped with HIV-1 HXB2 show no neutralization enhancement between TZM-bl cells and TZM-bl/FcγRI cells. Data points and error bars are the means and standard errors of the means (n = 2), respectively. (B) The degree of observed neutralization enhancement is FcγRI specific, as demonstrated by the neutralization potency of D5_AR IgG against lentivirus pseudotyped with HIV-1 HXB2 in TZM-bl cells expressing various Fc receptors. Data points and error bars are the means and standard errors of the means (n = 3), respectively.