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S protein amino acid variation and disorder in sarbecoviruses. Single-amino-acid polymorphism (SAP) and disorder/order of S protein. The average and 99% confidence interval are represented by the dotted line. The vertical gray line marks the location of the ACE2 receptor binding domain. (A) SARS-CoV-2. (B) Bat SARS-like coronavirus. (C) Bat SARS coronavirus.
