Table 2:
Case–control association analyses for DRB1 alleles in Arab T1D individuals and controls
| DRB1 Allele | Control Frequency (n) | Patient Frequency (n) | OR (95% CI) | p-value | Significance |
|---|---|---|---|---|---|
| 01:02 | 0.033 (13) | 0.018 (2) | 0.54 (0.06–2.42) | 4.09 × 10−01 | NS |
| 03:01 | 0.086 (34) | 0.321 (36) | 5.04 (2.86–8.86) | 1.70 × 10−10 | * |
| 04:01 | 0.01 (4) | 0.027 (3) | 2.7 (0.39–16.16) | 1.81 × 10−01 | NS |
| 04:02 | 0.01 (4) | 0.045 (5) | 4.58 (0.96–23.4) | 1.44 × 10−02 | * |
| 04:03 | 0.028 (11) | 0.018 (2) | 0.64 (0.07–2.98) | 5.57 × 10−01 | NS |
| 04:05 | 0.045 (18) | 0.134 (15) | 3.25 (1.46–7.08) | 7.96 × 10−04 | * |
| 07:01 | 0.073 (29) | 0.098 (11) | 1.38 (0.6–2.96) | 3.86 × 10−01 | NS |
| 08:04 | 0.109 (43) | 0.107 (12) | 0.99 (0.46–1.99) | 9.65 × 10−01 | NS |
| 10:01 | 0.073 (29) | 0.018 (2) | 0.23 (0.03–0.94) | 3.07 × 10−02 | * |
| 11:01 | 0.058 (23) | 0.054 (6) | 0.92 (0.3–2.4) | 8.56 × 10−01 | NS |
| 11:02 | 0.02 (8) | 0 (0) | 0 (0–2.07) | 1.29 × 10−01 | NS |
| 11:04 | 0.033 (13) | 0.018 (2) | 0.54 (0.06–2.42) | 4.09 × 10−01 | NS |
| 13:01 | 0.073 (29) | 0.027 (3) | 0.35 (0.07–1.16) | 7.40 × 10−02 | NS |
| 13:02 | 0.096 (38) | 0.036 (4) | 0.35 (0.09–1) | 4.09 × 10−02 | † |
| 13:03 | 0.04 (16) | 0.018 (2) | 0.43 (0.05–1.88) | 2.54 × 10−01 | NS |
| 15:02 | 0.061 (24) | 0.009 (1) | 0.14 (0–0.88) | 2.56 × 10−02 | * |
| 15:03 | 0.078 (31) | 0 (0) | 0 (0–0.42) | 2.25 × 10−03 | * |
| binned | 0.073 (29) | 0.054 (6) | 0.72 (0.24–1.82) | 4.68 × 10−01 | NS |
| TOTAL | 1 (396) | 1 (112) |
n: Number of observations of each allele; OR: Odds Ratio; CI: Confidence Interval; NS: Not Significant;
*:
Significant;
†:
Significance is questionable given the results of the resampling analyses; Binned: Alleles with low expected counts in subjects or controls were combined into a common category for analysis in BIGDAWG’s “non-strict binning” mode (Supplementary Table 3).