TABLE 1.

Comparison of the 5AVA production by different engineered microbial strains and production of amino acids by B. methanolicus.

Organism	Approach	5AVA titer [g l–1]	References
Pseudomonas putida KT2440	DavBA-based biocatalytic production of 5AVA from 30 g l–1 L-lysine	20.80	Liu et al., 2014
Corynebacterium glutamicum	Heterologous expression of davBA; sugar-based fed-batch fermentation	33.10	Shin et al., 2016
		28.00	Rohles et al., 2016
		39.93	Joo et al., 2017
	Heterologous expression of ldcC and patAD; shake flask fermentation	5.10	Jorge et al., 2017
	Heterologous expression of puo and patD, deletion of gabTD; microbioreactor fermentation	3.70	Haupka et al., 2020
Escherichia coli	Heterologous expression of davBA and deletion of cadA; glucose-based shaking flasks fermentation	0.86	Adkins et al., 2013
	Heterologous expression of davBA; sugar-based fermentation; 10 g l–1 lysine provided	3.60	Park et al., 2013
	Heterologous expression of davBA; sugar-based fed-batch fermentation	0.50	Park et al., 2013
	Heterologous expression of davBA; glucose-based fed- batch fermentation; 120 g l–1 L-lysine provided	90.59	Park et al., 2014
	Heterologous expression of davBA; fed-batch whole-cell bioconversion of L-lysine maintained at 120 g l–1	240.70	Wang et al., 2016
	Heterologous expression of raiP; whole-cell bioconversion; addition of 4% ethanol, 10 mM H2O2 and 100 g l–1 lysine	29.12	Cheng et al., 2018
	Heterologous expression of raiP; whole-cell bioconversion; 4% ethanol pretreatment, 10 mM H2O2 and 100 g l–1 lysine	50.62	Cheng et al., 2020
Organism	Product in methanol-controlled fed-batch fermentation	Titer [g L–1]	References
Bacillus methanolicus	L-Glutamate	60.00	Heggeset et al., 2012
	L-Lysine	11.00	Brautaset et al., 2010
	γ-Aminobutyric acid	9.00	Irla et al., 2017
	Cadaverine	11.30	Nærdal et al., 2015