TABLE 3.
Multivariate analysis of the effect of ABO incompatibility on the engraftment
| Neutrophil engraftment OR (95% CI) | Platelet engraftment OR (95% CI) | Reticulocyte engraftment OR (95% CI) | |
|---|---|---|---|
| Major ABO-Ia | 0.83 (0.63-1.09)P = 0.1805 | 0.75 (0.56-1.00)P = 0.0526 | 0.51 (0.38-0.70)P < 0.0001 |
| Minor ABO-Ia | 1.19 (0.89-1.58)P = 0.2160 | 1.12 (0.84-1.50)P = 0.4328 | 1.15 (0.86-1.54)P = 0.3317 |
| Bidirectional ABO-Ia | 1.07 (0.71-1.61)P = 0.7395 | 1.17 (0.77-1.78)P = 0.4449 | 0.84 (0.55-1.29)P = 0.4406 |
| NMA conditioning | 0.78 (0.62-0.99)P = 0.0456 | 0.63 (0.49-0.80)P = 0.0002 | 0.65 (0.51-0.83)P = 0.0007 |
| BM graft | 0.97 (0.68-1.38)P = 0.8763 | 0.70 (0.49-1.01)P = 0.0593 | 0.63 (0.43-0.91)P = 0.0143 |
| CD34+ cells × 106/kg | 1.01 (0.97-1.04)P = 0.5562 | 1.03 (1.00-1.07)P = 0.0420 | 1.02 (0.99-1.06)P = 0.1276 |
| Haploidentical donorb | 0.84 (0.59-1.19)P = 0.3443 | 0.69 (0.48-0.99)P = 0.0462 | 0.98 (0.67-1.42)P = 0.9177 |
| 8/8 MUDb | 0.93 (0.70-1.25)P = 0.6595 | 0.70 (0.52-0.95)P = 0.0225 | 0.95 (0.70-1.30)P = 0.7929 |
| 7/8 MUDb | 1.04 (0.69-1.55)P = 0.8361 | 1.04 (0.70-1.56)P = 0.8229 | 1.51 (0.99-2.28)P = 0.0501 |
| Myeloid neoplasm | 0.90 (0.70-1.16)P = 0.4442 | 0.69 (0.53-0.89)P = 0.0050 | 0.68 (0.60-1.01)P = 0.0680 |
| Complete remission | 1.09 (0.86-1.37)P = 0.4393 | 0.97 (0.77-1.23)P = 0.8069 | 0.93 (0.73-1.18)P = 0.5714 |
| Discordant CMV serology | 0.83 (0.66-1.05)P = 0.1258 | 0.91 (0.72-1.16)P = 0.4833 | 1.03 (0.81-1.32)P = 0.7838 |
| Mo from diagnosis | 1.00 (0.99-1.00)P = 0.9998 | 0.99 (0.99-1.00)P = 0.6841 | 0.99 (0.99-1.00)P = 0.5858 |
Significant P values are highlighted in bold.
avs ABO-matched.
bvs HLA-identical donor.
ABO-I, ABO incompatibility; BM, bone marrow; CI, confidence interval; CMV, cytomegalovirus; MUD, matched unrelated donor; NMA, nonmyeloablative; OR, odds ratio.