TABLE 4.
Multivariate analysis of the effect of ABO incompatibility on acute (grade II–IV) and chronic (moderate-severe) graft-vs-host disease
| Acute GVHD OR (95% CI) | Chronic GVHD OR (95% CI) | |
|---|---|---|
| Major ABO-Ia | 1.18 (0.66-1.10)P = 0.5674 | 0.84 (0.48-1.49)P = 0.5684 |
| Minor ABO-Ia | 0.67 (0.33-1.33)P = 0.2596 | 0.83 (0.474-1.44)P = 0.5188 |
| Bidirectional ABO-Ia | 1.68 (0.82-3.44)P = 0.1489 | 1.13 (0.58-2.18)P = 0.7140 |
| NMA conditioning | 1.14 (0.72-1.82)P = 0.5557 | 0.87 (0.58-1.32)P = 0.5328 |
| Haploidentical donorb | 1.77 (0.67-4.63)P = 0.2422 | 1.60 (0.66-3.87)P = 0.2982 |
| 8/8 MUDb | 1.48 (0.80-2.74)P = 0.2099 | 0.84 (0.49-1.45)P = 0.5434 |
| 7/8 MUDb | 2.39 (1.13-5.06)P = 0.0225 | 0.52 (0.21-1.24)P = 0.1426 |
| Female donor to male recipient | 0.89 (0.45-1.78)P = 0.7590 | 1.12 (0.66-1.90)P = 0.6603 |
| Bone marrow graft | 0.58 (0.20-1.65)P = 0.3081 | 0.28 (0.10-0.76)P = 0.0125 |
| CD34+ cells × 106/kg | 1.04 (0.97-1.12)P = 0.1815 | 0.91 (0.84-0.99)P = 0.0383 |
| CD3+ cells × 106/kg | 0.99 (0.99-1.00)P = 0.7880 | 1.00 (0.99-1.00)P = 0.2066 |
| Discordant CMV serology | 1.06 (0.65-1.74)P = 0.7929 | 0.81 (0.50-1.30)P = 0.3916 |
Cell doses were considered as continuous variables.
Significant P values are highlighted in bold.
avs ABO-matched.
bvs HLA identical donor.
ABO-I, ABO incompatibility; CI, confidence interval; CMV, cytomegalovirus; GVHD, graft-vs-host disease; MUD, matched unrelated donor; NMA, nonmyeloablative; OR, odds ratio.