Table 4.
Fold change in lipid metabolites in HFCS-exposed 30-week-old animals
| Female | q value | Male | q value | ||
|---|---|---|---|---|---|
| Essential fatty acid | Linoleate (18:2n6) | 1.37 | 0.0453 | 1.08 | 0.8896 |
| Linolenate [alpha or gamma; (18:3n3 or 6)] | 1.64 | 0.0562 | 0.93 | 0.8794 | |
| Dihomo-linolenate (20:3n3 or n6) | 1.22 | 0.1051 | 1.01 | 0.9107 | |
| Eicosapentaenoate (EPA; 20:5n3) | 1.49 | 0.0583 | 0.88 | 0.8144 | |
| Docosapentaenoate (n3 DPA; 22:5n3) | 1.47 | 0.0931 | 0.89 | 0.8144 | |
| Docosapentaenoate (n6 DPA; 22:5n6) | 0.9 | 0.3702 | 0.94 | 0.8098 | |
| Docosahexaenoate (DHA; 22:6n3) | 1.1 | 0.1744 | 1.01 | 0.9043 | |
| Medium chain fatty acid | Caproate (6:0) | 1.02 | 0.8949 | 0.79 | 0.7536 |
| Long chain fatty acid | Myristate (14:0) | 1.39 | 0.0927 | 1.2 | 0.8713 |
| Myristoleate (14:1n5) | 1.33 | 0.3186 | 1.39 | 0.6653 | |
| Pentadecanoate (15:0) | 1.21 | 0.4386 | 1.13 | 0.8144 | |
| Palmitate (16:0) | 1.27 | 0.05 | 1.09 | 0.8519 | |
| Palmitoleate (16:1n7) | 1.51 | 0.0478 | 1.25 | 0.8519 | |
| Margarate (17:0) | 1.38 | 0.0405 | 0.92 | 0.8144 | |
| 10-Heptadecenoate (17:1n7) | 1.58 | 0.0397 | 1.1 | 0.9043 | |
| Stearate (18:0) | 1.15 | 0.0628 | 0.97 | 0.8713 | |
| Oleate (18:1n9) | 1.5 | 0.077 | 1.34 | 0.7391 | |
| cis-Vaccenate (18:1n7) | 1.01 | 0.8225 | 1.59 | 0.4047 | |
| Stearidonate (18:4n3) | 1.88 | 0.115 | 0.72 | 0.6859 | |
| Nonadecanoate (19:0) | 1.06 | 0.5027 | 0.9 | 0.6091 | |
| 10-Nonadecenoate (19:1n9) | 1.38 | 0.081 | 1.16 | 0.8794 | |
| Eicosenoate (20:1n9 or 11) | 1.55 | 0.0531 | 1.13 | 0.9043 | |
| Dihomo-linoleate (20:2n6) | 1.36 | 0.0959 | 1.06 | 0.931 | |
| Mead acid (20:3n9) | 1.24 | 0.1171 | 1.06 | 0.9043 | |
| Arachidonate (20:4n6) | 1.07 | 0.2503 | 1.09 | 0.6653 | |
| Erucate (22:1n9) | 0.97 | 0.7327 | 0.89 | 0.6886 | |
| Docosadienoate (22:2n6) | 0.93 | 0.6197 | 0.95 | 0.888 | |
| Adrenate (22:4n6) | 1.13 | 0.5555 | 0.84 | 0.6653 | |
| Fatty acid, monohydroxy | 16-Hydroxypalmitate | 0.89 | 0.3447 | 0.99 | 0.9043 |
| 2-Hydroxystearate | 1.14 | 0.2191 | 0.99 | 0.9043 | |
| 13-HODE + 9-HODE | 1.4 | 0.0737 | 0.81 | 0.6653 | |
| Fatty acid, dicarboxylate | 2-Hydroxyglutarate | 0.89 | 0.6562 | 0.97 | 0.8794 |
| Hexadecanedioate | 0.9 | 0.5997 | 1.08 | 0.9115 | |
| Fatty acid, branched | 15-Methylpalmitate (isobar with 2-methylpalmitate) | 1.13 | 0.3325 | 1 | 0.9043 |
| 17-Methylstearate | 1.33 | 0.0029 | 0.89 | 0.6653 | |
| Eicosanoid | 12-HETE | 1.05 | 0.5579 | 1.15 | 0.6653 |
| Endocannabinoid | Palmitoyl ethanolamide | 1.16 | 0.2486 | 0.83 | 0.6653 |
| N-Palmitoyl taurine | 1.09 | 0.5931 | 1.62 | 0.4646 | |
| Fatty acid metabolism (also BCAA metabolism) | Propionylcarnitine | 0.83 | 0.2304 | 0.95 | 0.8896 |
| Hydroxybutyrylcarnitin | 1.46 | 0.0505 | 1.15 | 0.8506 | |
| Butyrylglycine | 0.5 | 0.018 | 0.96 | 0.9043 | |
| Fatty acid synthesis | Malonylcarnitine | 0.96 | 0.8363 | 1.03 | 0.9043 |
| Carnitine metabolism | Deoxycarnitine | 0.77 | 0.0422 | 0.77 | 0.4402 |
| Carnitine | 1.15 | 0.039 | 1.11 | 0.6091 | |
| 3-Dehydrocarnitine | 1.11 | 0.3026 | 1.32 | 0.1607 | |
| Acetylcarnitine | 1.02 | 0.8488 | 0.89 | 0.8029 | |
| Glycerolipid metabolism | Choline phosphate | 0.95 | 0.59 | 1.22 | 0.6653 |
| Ethanolamine | 0.94 | 0.8288 | 1.07 | 0.8794 | |
| Phosphoethanolamine | 0.57 | 0.0207 | 1.44 | 0.5858 | |
| Glycerol | 1.31 | 0.0722 | 1.19 | 0.7014 | |
| Choline | 0.97 | 0.5877 | 1.01 | 0.9043 | |
| Glycerol 3-phosphate (G3P) | 1.39 | 0.0571 | 0.86 | 0.8144 | |
| Glycerophosphorylcholine (GPC) | 0.97 | 0.8181 | 0.75 | 0.6091 | |
| Cytidine 5′-diphosphocholine | 1.06 | 0.5071 | 1.05 | 0.8879 |
Significance determined by two-way ANOVA, where sex and treatment were factors and corrected for multiple testing using the FDR. N = 8 per group.