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. Author manuscript; available in PMC: 2021 Jul 12.
Published in final edited form as: Mol Pharm. 2019 Jun 21;16(7):3253–3260. doi: 10.1021/acs.molpharmaceut.9b00453

Figure 1.

Figure 1.

Comparison of four different previously known heptamethine cyanines. Images shown of rat abdomen 10 min following injection. Description of properties: Net charge, net charge at neutral pH; # of Charges, number of charged functional groups at neutral pH; CLogP, calculated using sodium and chloride counterions.34 Excretion to biliary tract: + +, high excretion into the bile (CLR > 3); +, low excretion into bile (CLR < 3); −−−, no detectable bile signal and time to maximal detectable signal. CLR, ratio of common bile duct to liver fluorescence signal. Specificity: ratio of biliary and urinary signals at 10 min time point. Yellow arrows: CA = cystic artery, GB = gallbladder, CD = cystic duct, CBD = common bile duct, LP = liver parenchyma, EHD = extrahepatic duct, KD = kidney, UT = ureter, DD = duodenum.