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. 2021 Jun 28;15:664312. doi: 10.3389/fncel.2021.664312

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Copyright © 2021 Pan, Tian, Wang, Zhao, Zhang, Wang, Xie, Zhang, Zhu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of perforin-mediated neurotoxicity facilitates neurogenesis. (A) Flow cytometry was used to detect astrocytes and neuron stem/progenitor cells by according to Glast and 7AAD expression, and these cells were divided into Glast⁺ and Glast^– subtypes 14 days after ischemia surgery and sham operation group in the focal ischemic brain area. Then, these three subtypes were divided into stem/progenitor cells according to CD133 and CD24 expression. (B,C) The box graph shows the numbers of mature astrocytes and glial progenitors. The data are shown as the median and the value of min to max; n = (6–10) animals in each group. Prf1^–/– mice vs. WT mice at each time point. **P < 0.01.