TABLE 1.

Inclusion and exclusion criteria

Inclusion criteria

. Age >18 years and <79 years.

. Availability of complete required data.

. Ethnic Han population.

. Matched individuals with age and gender (which mean that gender groups (male group and female group) and every subgroup (18–29, 30–39, 40–49, 50–64 and 65–79 years subgroups) to have an approximately equal number of the individuals.)

Exclusion criteria

. Presence of any known medical condition (comorbidities).

. Pregnancy.

. History or continued use of alcohol, tobacco, or oral contraceptives.

. Abnormal results of clinical laboratory, such as white blood cell count <3.0 × 109/L or >12.5 × 109/L, Abnormal urinalysis results, etc.

. Any surgery within 6 months after enrollment.

. Blood donation or transfusion within 4 months of enrollment.

. Body mass index (BMI)>28 kg/m2.