TABLE 4.

AMH performance characteristics according to age groups

Age group (years)	No. of PCOS cases	Controls (n)	AUCROC (95% CI)	Condition	Cutoff value	Youden's J	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
12–20	87	Healthy (42)	0.741 (0.641–0.840)	At 95% sensitivity	1.76	0.359	0.954 (0.888–0.982)	0.405 (0.270–0.555)	0.769 (0.720–0.811)	0.810 (0.604–0.922)
				Maximum Youden's J	4.12	0.437	0.770 (0.671–0.846)	0.667 (0.516–0.790)	0.827 (0.755–0.882)	0.583 (0.474–0.685)
				At 95% specificity	10.59	0.125	0.172 (0.107–0.265)	0.952 (0.842–0.987)	0.882 (0.642–0.969)	0.357 (0.331–0.385)
		Benign (115)	0.679 (0.606–0.753)	At 95% sensitivity	1.85	0.215	0.954 (0.888–0.982)	0.261 (0.189–0.348)	0.494 (0.465–0.524)	0.882 (0.733–0.953)
				Maximum Youden's J	3.96	0.297	0.793 (0.696–0.865)	0.504 (0.414–0.594)	0.548 (0.494–0.600)	0.763 (0.673–0.835)
				At 95% specificity	11.38	0.106	0.149 (0.089–0.239)	0.957 (0.902–0.981)	0.722 (0.491–0.875)	0.598 (0.574–0.621)
		All (157)	0.696 (0.630–0.762)	At 95% sensitivity	1.85	0.253	0.954 (0.888–0.982)	0.299 (0.233–0.375)	0.430 (0.403–0.458)	0.922 (0.814–0.969)
				Maximum Youden's J	4.16	0.324	0.770 (0.671–0.846)	0.554 (0.476–0.630)	0.489 (0.437–0.541)	0.813 (0.743–0.868)
				At 95% specificity	11.38	0.105	0.149 (0.089–0.239)	0.955 (0.911–0.978)	0.650 (0.435–0.818)	0.670 (0.648–0.690)
21–34	308	Healthy (161)	0.785 (0.740–0.830)	At 95% sensitivity	2.40	0.330	0.951 (0.921–0.970)	0.379 (0.308–0.456)	0.746 (0.721–0.768)	0.803 (0.705–0.874)
				Maximum Youden's J	5.67	0.462	0.692 (0.638–0.741)	0.770 (0.699–0.828)	0.852 (0.811–0.885)	0.566 (0.520–0.612)
				At 95% specificity	11.30	0.178	0.227 (0.184–0.277)	0.950 (0.905–0.975)	0.897 (0.812–0.947)	0.391 (0.375–0.408)
		Benign (331)	0.719 (0.680–0.758)	At 95% sensitivity	2.40	0.238	0.951 (0.921–0.970)	0.287 (0.241–0.338)	0.554 (0.536–0.572)	0.864 (0.790–0.914)
				Maximum Youden's J	5.69	0.356	0.692 (0.638–0.741)	0.665 (0.612–0.713)	0.657 (0.618–0.694)	0.698 (0.658–0.736)
				At 95% specificity	14.03	0.098	0.146 (0.111–0.190)	0.952 (0.923–0.970)	0.738 (0.619–0.830)	0.545 (0.532–0.558)
		All (492)	0.740 (0.706–0.775)	At 95% sensitivity	2.40	0.268	0.951 (0.921–0.970)	0.317 (0.278–0.359)	0.466 (0.450–0.482)	0.912 (0.862–0.945)
				Maximum Youden's J	5.69	0.391	0.692 (0.638–0.741)	0.699 (0.657–0.738)	0.590 (0.552–0.627)	0.784 (0.752 0.812)
				At 95% specificity	13.28	0.114	0.162 (0.125–0.208)	0.951 (0.928–0.967)	0.676 (0.567–0.768)	0.645 (0.632–0.657)
35–46	45	Healthy (126)	0.789 (0.704–0.874)	At 95% sensitivity	0.07	0.154	0.956 (0.852–0.988)	0.198 (0.138–0.277)	0.299 (0.277–0.322)	0.926 (0.755–0.981)
				Maximum Youden's J	1.90	0.508	0.778 (0.637–0.875)	0.730 (0.647–0.800)	0.507 (0.426–0.588)	0.902 (0.841–0.941)
				At 95% specificity	5.21	0.397	0.444 (0.309–0.588)	0.952 (0.900–0.978)	0.769 (0.588–0.886)	0.828 (0.787–0.862)
		Benign (286)	0.778 (0.698–0.858)	At 95% sensitivity	0.07	0.158	0.956 (0.852–0.988)	0.203 (0.160–0.253)	0.159 (0.148–0.170)	0.967 (0.880–0.991)
				Maximum Youden's J	3.55	0.471	0.600 (0.455–0.730)	0.871 (0.827–0.905)	0.422 (0.332–0.517)	0.933 (0.906–0.952)
				At 95% specificity	5.93	0.284	0.333 (0.214–0.479)	0.951 (0.920–0.971)	0.517 (0.357–0.674)	0.901 (0.880–0.918)
		All (412)	0.782 (0.702–0.861)	At 95% sensitivity	0.07	0.157	0.956 (0.852–0.988)	0.201 (0.166–0.243)	0.116 (0.108–0.124)	0.976 (0.914–0.994)
				Maximum Youden's J	3.55	0.467	0.600 (0.455–0.730)	0.867 (0.830–0.896)	0.329 (0.258–0.409)	0.952 (0.933–0.966)
				At 95% specificity	5.65	0.329	0.378 (0.251–0.524)	0.951 (0.926–0.968)	0.459 (0.325–0.600)	0.933 (0.918–0.946)

Abbreviations: AMH, anti‐Müllerian hormone; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.