Table 2.
Antimalarial Activity Test of the Hydroalcoholic Crude Extract and Solvent Fractions of Zehneria Scabra Roots, Against P. Berghei in the Four-Day Suppressive Test
| Rx Group | % Parasitemia | % Suppression | Survival Time |
|---|---|---|---|
| CON | 41.51±1.73 | 0.00 | 7.17±0.11 |
| ZS200 | 20.61±1.62 | 50.35a3b3d2e3 | 9.00±0.47a2b3d2e3 |
| ZS400 | 16.48±0.49 | 60.31a3b3e2 | 10.83±0.36a3b3e2 |
| ZS600 | 11.18±0.56 | 73.08a3b3 | 12.50±0.18a3b3 |
| CQ25 | 0.00±0.00 | 100.00a3 | 28.00±0.00a3 |
| CON | 42.29±1.56 | 0.00 | 7.17±0.11 |
| CF200 | 20.38±0.92 | 51.82a3b3d2e3 | 8.42±0.30b3e3 |
| CF400 | 17.61±0.58 | 58.36 a3b3e3 | 9.33±0.40a2b3e3 |
| CF600 | 13.32±0.44 | 68.50 a3b3 | 13.00±0.53a3b3 |
| CQ25 | 0.00±0.00 | 100.00a3 | 28.00±0.00a3 |
| CON | 44.60±1.99 | 0.00 | 6.92±0.30 |
| BF200 | 22.58±0.61 | 49.37a3b3d3e3 | 9.00±0.37a2b3d3e3 |
| BF400 | 15.64±0.84 | 64.93a3b3e3 | 14.42±0.57a3b3 |
| BF600 | 11.45±0.66 | 74.33 a3b3 | 15.83±0.44 a3b3 |
| CQ25 | 0.00±0.00 | 100.00a3 | 28.00±0.00a3 |
| CON | 43.74±1.73 | 0.00 | 7.25±0.44 |
| WF200 | 36.56±0.57 | 16.43a3b3d3e3 | 7.83±0.25b3e1 |
| WF400 | 30.44±0.61 | 30.41a3b3e2 | 8.42±0.24b3 |
| WF600 | 27.24±1.09 | 37.72a3 | 9.25±0.38a2b3 |
| CQ 25 | 0.00±0.00 | 100.00 | 28.00±0.00a3 |
Notes: Data are expressed as mean±SEM (n=6); acompared to CON; b,CQ25; d400mg/kg; e, 600mg/kg:1p<0.05, 2p<0.01, 3p<0.001; CON, negative control, received distilled water 10 mL/kg; ZS = crude extract of Zehneria scabra root, CF = chloroform fraction of Zehneria scabra, BF = Butanol fraction of Zehneria scabra, WF = water fraction of Zehneria scabra, and CQ = chloroquine; numbers (25,200,400,600) refer to dose in mg/kg.