Table 3.
Analysis of Prognostic Factors Using Univariate and Multivariate Analyses Among the 152 Followed-Up ESCC Patients
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age (y), >60 | 1.058 (0.711–1.574) | 0.781 | ||
| Gender, man | 0.947 (0.528–1.697) | 0.854 | ||
| Smoking, >5/day | 1.058 (0.703–1.592) | 0.788 | ||
| Alcohol, >25 g/day | 1.320 (0.878–1.985) | 0.182 | ||
| Tumor site, U | 1 | 1 | ||
| M | 0.351 (0.163–0.758) | 0.008** | 0.301 (0.13–0.696) | 0.005** |
| L | 0.380 (0.176–0.82) | 0.014* | 0.264 (0.114–0.611) | 0.002** |
| Tumor size, ≤3 cm | 1 | |||
| 3–5 cm | 1.260 (0.823–1.929) | 0.287 | ||
| >5 cm | 1.333 (0.614–2.893) | 0.467 | ||
| DTCD, Well | 1 | 1 | ||
| Moderate | 1.338 (0.88–2.033) | 0.173 | 0.964 (0.471–1.974) | 0.483 |
| Low | 2.535 (1.247–5.156) | 0.010* | 1.002 (0.499–2.011) | 0.737 |
| No. of LNs metastasized, 0 | 1 | 1 | ||
| 1–2 | 3.274 (2.052–5.223) | <0.001** | 1.664 (0.784–3.532) | 0.185 |
| ≥3 | 4.637 (2.688–7.999) | <0.001** | 2.593 (1.038–6.476) | 0.041* |
| Pathological type, ME | 1 | |||
| UT | 1.566 (0.898–2.732) | 0.114 | ||
| MU | 1.282 (0.466–3.531) | 0.63 | ||
| CT | 0.608 (0.139–2.661) | 0.509 | ||
| Pathological stage, I | 1 | 1 | ||
| II | 1.582 (0.681–3.675) | 0.286 | 1.272 (0.53–3.049) | 0.590 |
| III | 5.591 (2.389–13.085) | <0.001** | 2.235 (0.79–6.324) | 0.130 |
| IV | 7.934 (2.216–28.403) | 0.001** | 3.645 (0.847–15.678) | 0.082 |
| Ki-67, 0–25% | 1 | |||
| 25–50% | 0.952 (0.537–1.685) | 0.865 | ||
| >50% | 1.040 (0.579–1.867) | 0.895 | ||
| P53, 0–25% | 1 | |||
| 25–50 | 0.642 (0.294–1.398) | 0.264 | ||
| 50–75 | 1.294 (0.665–2.518) | 0.448 | ||
| >75% | 0.848 (0.484–1.487) | 0.565 | ||
| nm23, 0–25% | 1 | |||
| 25–50% | 0.945 (0.557–1.602) | 0.833 | ||
| 50–75% | 0.748 (0.382–1.467) | 0.398 | ||
| >75% | 0.625 (0.341–1.144) | 0.127 | ||
| PABPC1, low expression | 1 | 1 | ||
| PABPC1, high expression | 3.178 (2.092–4.829) | <0.001** | 2.622 (1.68–4.129) | <0.001** |
Notes: Significance analysis was two-tailed, and p<0.05 was considered statistically significant. * at p<0.05 level, ** at p<0.01 level.
Abbreviations: ESCC, esophageal squamous cell carcinoma; U, upper esophagus; M, middle esophagus; L, lower esophagus; DTCD, degree of tumor cell differentiation; LN, lymph node; ME, medullary type; UT, ulcerative type; MU, mushroom type; CT, constrictive type.