Table 5.
Multivariate analysis of factors associated with the choice of crystalloid or colloid for fluid resuscitation episodes in Brazilian patients
| Variable | Crystalloid given OR (95%CI) |
p value | Colloid given OR (95%CI) |
p value |
|---|---|---|---|---|
| Admission characteristics | ||||
| Operating room after elective surgery | 1.0 | 0.215 | 1.0 | 0.1144 |
| Emergency room | 1.0 (0.3 - 2.9) | 0.6 (0.2 - 1.5) | ||
| Hospital floor | 3.0 (0.3 - 26.8) | 0.2 (0.0 - 1.2) | ||
| Transferred from other ICU or hospital | 2.5 (0.3 - 22.6) | 0.7 (0.2 - 3.1) | ||
| Operating room after emergency surgery | 0.6 (0.1 - 2.6) | 0.8 (0.2 - 2.7) | ||
| Hospital floor after previous ICU stay | 0.3 (0.1 - 1.1) | 2.4 (0.8 - 7.5) | ||
| Fluid prescriber | ||||
| Specialist/assistant physician | 1.0 | < 0.0001 | 1.0 | 0.1483 |
| Senior resident/fellow | 9.9 (3.6 - 27.7) | 0.2 (0.0 - 1.1) | ||
| Resident | 0.6 (0.1 - 3.9) | 1.4 (0.3 - 6.5) | ||
| Metabolic acidosis | ||||
| No | 1.0 | 0.241 | 1.0 | 0.2207 |
| Yes | 0.5 (0.1 - 1.8) | 1.3 (0.5 - 3.4) | ||
| Missing | 0.3 (0.1 - 1.2) | 2.5 (0.9 - 7.1) | ||
| Lactate (mmol/L) categories | ||||
| < 2 | 1.0 | 0.394 | 1.0 | 0.8014 |
| ≥ 2 | 0.9 (0.2 - 3.5) | 0.8 (0.3 - 2.1) | ||
| Missing | 0.4 (0.1 - 1.8) | 1.1 (0.4 - 3.0) | ||
| Mean arterial pressure (per 10mmHg decrease) | 1.2 (1.0 - 1.5) | 0.012 | 0.9 (0.7 - 1.0) | 0.0669 |
| Albumin (g/L) categories | ||||
| < 27 | 1.0 | 0.001 | 1.0 | < 0.0001 |
| ≥ 27 | 8.6 (0.8 - 89.8) | 0.2 (0.0 - 0.9) | ||
| Missing | 7.2 (2.5 - 20.7) | 0.2 (0.1 - 0.4) |
OR - odds ratio; 95%CI - 95% confidence interval; ICU - intensive care unit. The results were generated from a generalized estimating equation model with patient ID as a cluster, using two binary outcomes in the analysis: (1) crystalloid episode Yes versus crystalloid episode No, and (2) colloid episode Yes versus colloid episode No. The denominators of these two outcomes were the total number of fluid episodes; thus, a given patient could have received a crystalloid as well as a colloid within the same hour (the same fluid episode). The analysis included 844 episodes from 503 study participants, as data were lost due to missing values that could not be included in the multivariate analysis. This number represents a loss of 4.1% of episodes and 3.1% of study participants.