Figure 6. Cortical-habenular coherence in the theta/alpha band is also differentially modulated by stimuli with positive and negative emotional valence (N = 16 local field potential-magnetoencephalography [LFP-MEG] combination samples from eight subjects).
(A) Time-varying theta (5–10 Hz) habenula-cortical coherence changes relative to pre-cue baseline averaged across all MEG channel combinations for each recorded habenula. The thick colored lines and shaded area show the mean and standard error across all recorded habenula. The coherence was significantly higher at 800–1300 ms after the onset of negative emotional stimuli compared to positive stimuli (rectangular shadow showing the time window with p<0.05). (B) Scalp plot showing the cortical-habenula coherence in the theta band during the identified time window (800–1300 ms) for positive stimuli (left), negative stimuli (middle), and statistical t-values and sensors with significant difference (right) masked at p<0.05 (corrected for whole-brain sensors). (C) The increase in the theta band coherence between right frontal cortex and habenula at 800–1300 ms correlated with the theta increase in habenula at 2700–3300 ms after stimuli onset. (D) Statistical source maps of t-values (p<0.05; uncorrected) for the comparison of theta/alpha coherence response in the time window of 800–1300 ms between negative stimuli with positive stimuli. The peak coherence differences were mainly localized in the right Brodmann area 10, MNI coordinate [10, 64, 12].
Figure 6—figure supplement 1. Time-varying coherence changes for frontal cortex-habenula and occipital cortex-habenula separately.
