Skip to main content
. 2021 Jun 28;12:680188. doi: 10.3389/fimmu.2021.680188

Figure 2.

Figure 2

COVID-19 patients responding to remdesivir (RDV) treatment show up-regulation of recovery-associated immune mediators. Growth factors brain-derived neurotropic factor (BDNF), placental growth factor (PIGF-1) and platelet-derived growth factor BB subunit (PDGF-BB) levels in plasma before and after RDV treatment in non-intubated responders (n = 21, median 9 and 16 days post-illness onset (PIO), respectively) and intubated non-responders (n = 6, median 7 and 13 days PIO, respectively), and matched timepoint 1 and 2 in non-RDV-treated non-intubated (n = 17, median 10 and 16 days PIO, respectively) and intubated (n = 10, median 6 and 12 days PIO, respectively) controls. Statistical analyses were performed with Wilcoxon matched-pairs signed rank test when comparing between timepoints, and Mann Whitney U test when comparing across groups (ns, not significant. *P < 0.05; **P < 0.01). Immune mediator levels for healthy controls (n=23) are indicated by the black dotted line. Patient samples with concentration out of measurement range are presented as the value of Limit of Quantification (LOQ).