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. 2021 Jul 8;13:5443–5455. doi: 10.2147/CMAR.S305946

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© 2021 Chen et al.

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Silencing of lncRNA HOXA-AS2 inhibited OSCC tumor growth by releasing miR-567 to inhibit the expression of CDK8. TSCCA and SCC-9 cells with si-LncRNA HOXA-AS2 or its negative control were injected into nude mice to establish xenograft OSCC tumor models. (A) Images of tumor nodules excised at the end of the study. (B and C) The tumor volume and weight were analyzed. (D) The miR-567 expression in tumor tissues. (E) The CDK8 mRNA expression in the node mice tumor tissues were determined by RT-qPCR. (F) The CDK8 protein level in the node mice tumor tissues were determined by Western Blot. *Means P <0.05, **Means P<0.01, and ***Means P<0.001.