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. 2021 Jul 12;37(Suppl 1):i237–i244. doi: 10.1093/bioinformatics/btab294

Table 1.

Comparison of amino acid embeddings

Embedding ROC-AUC
Biophysical features 0.76 ± 0.01
Learned embedding 0.75 ± 0.01
BLOSUM62 matrix 0.75 ± 0.01

Note: Mean and standard deviation of the AA CDR3 model configuration on 10-fold TCR split of the VDJ dataset. All tested amino acid embeddings show a similar performance.