Table 1.

Pharmacokinetic parameters after rectal administration of the conventional hydrogel and TPT-SLNs-TRHS and intravenous administration of TPT solution.

Parameters	TPT solution (IV)	Conventional hydrogel	TPT-SLNs-TRHS	TPT solution (IV)
AUC (ng h/mL)	1375.34 ± 139.74∗∗	163.69 ± 17.31	456.23 ± 59.62∗	1375.34 ± 139.74∗∗
T max(h)	—	1.43 ± 0.30	2.01 ± 0.30∗	—
C max (ng/mL)	940.67 ± 80.89∗∗	77.69 ± 17.53	112.60 ± 25.43∗	940.67 ± 80.89∗∗

Each value represents the mean ± S.D(n = 6).^∗P < 0.05 compared to conventional hydrogel. ^∗∗P < 0.05 compared to conventional hydrogel and TPT-SLNs-TRHs.