Table 1.
Some key target genes or proteins in the process of liver ischemia-reperfusion injury.
| Target | Classification | Function | Drug | Refs. (PMID) |
|---|---|---|---|---|
| ROS | ROS inhibitor | Inhibitor oxidative stress | Rotenone | 22706634 |
| SPG7 | 26387735 | |||
| HO-1 | 28842295 | |||
| Melatonin | 26993080 | |||
| Drp1 | Drp1 agonist | Promotes mitochondrial fission and apoptosis | ALR | 33110216 |
| Drp1 inhibitor | Inhibits mitochondrial fission and apoptosis | HSS | 28646508 | |
| Inhibits mitochondrial fission and apoptosis | Irisin | 30388684 | ||
| P53 | P53 agonist | Promotes mitochondrial fission and apoptosis | GOX | 26884717 |
| P53 inhibitor | Inhibits the formation of mPTP | CsA | 30496631 | |
| C31 | 31336123 | |||
| SPG7 | 26387735 | |||
| MFN2 | MFN2 agonist | Inhibits abnormal mitophagy | SIRT1 | 26184910 |
| Nrf2 | Nrf2 agonist | Inhibits oxidative stress | Cilostazol | 25951827 |
| Brg1 | 28569786 | |||
| Nrf2 inhibitor | Promotes oxidative stress | ATF | 25359217 | |
| HO-1 | HO-1 agonist | Inhibits mitochondrial fission and apoptosis | Bach1 | 30145824 |
| HO-1 inhibitor | Promotes mitochondrial fission and apoptosis | ZnPP | 25319231 |