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. 2021 Jul 4;2021:5707242. doi: 10.1155/2021/5707242

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Copyright © 2021 Fangbing Zhu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Curculigoside treatment inhibited Ti-induced activation of osteoclast activity in BMSCs. (a) After being intervened with Ti and treated with curculigoside at different concentrations (25, 50, and 100 μg/ml) for 48 h, BMSC viability was detected by the CCK-8 assay (n = 6). (b) The levels of TNF-α, IL-1β, and IL-6 in BMSCs were detected using ELISA kits. (c) Cellular immunofluorescence of F-actin in BMSCs (n = 3); results are represented as the mean ± SD. ^▲P < 0.05, compared to the Con group; ^▲▲P < 0.01, compared to the Con group; ^∗P < 0.05, compared to the Ti group; ^∗∗P < 0.01, compared to the Ti group. BMSCs: bone marrow stromal cells; Ti: titanium particles; Con: control.