Pediatric multiple sclerosis (MS) should be addressed holistically, including its effects on mood and cognition and the functional impact on school performance.

Children with MS should be on disease-modifying therapies, be encouraged to take vitamin D3, reduce saturated fat intake, exercise, avoid smoking, practice good sleep hygiene, and receive appropriate treatment for any mood disorders.

Behavioral interventions, including targeted cognitive, physical, or occupational therapies, should be warranted in pediatric MS.