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. 2020 Nov 4;60(5):2449–2467. doi: 10.1007/s00394-020-02426-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Dose–response association between 100% fruit juice consumption and cardiovascular events. a Risk of total cardiovascular (CV) events. b Risk of stroke events. c Risk of coronary heart disease (CHD). 100% fruit juice consumption was modelled with restricted cubic splines in a multivariate random-effects dose–response model (solid line). Dashed lines represent the 95% confidence intervals for the spline model