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. 2021 Jul 12;12:4251. doi: 10.1038/s41467-021-24524-8

Fig. 2. CSF Neurotransmitter metabolites.

Fig. 2

Concentrations of CSF metabolites measured at 2 separate baseline (BL) timepoints, Month 3, Month 6, and Month 12, in individual subjects in Cohort 1 (low-dose, black markers); and Cohort 2 (high-dose, white markers) and summarized at each timepoint as the group median (bars). A Homovanillic acid (HVA), the dopamine metabolite, was significantly higher at each post-operative timepoint compared to the baseline mean (inverted bracket; (*p = 0.0078 at Months 3 and 6, p = 0.0313 at Month 12, one-tailed Wilcoxon signed-rank test). Lower limit of normal range: 218 nmol/L (dotted line). B 5-hydroxyindoleacetic acid (5-HIAA), the serotonin metabolite, did not change after gene delivery. Lower limit of normal range: 66 nmol/L (dotted line). C 3-O-methyldopa (3-OMD) was elevated in all subjects at all timepoints. Normal: <100 nmol/L (dotted line). Source data can be found in Table 2.